SS-31 10MG

SS-31 10MG

LE 12,000.00
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SS-31 10MG
  • SS-31 10MG
  • SS-31 10MG
SS-31 10MG

SS-31 10MG

LE 12,000.00

SS-31 10mg: Technical Description

SS-31 (also known as Elamipretide, Bendavia, or MTP-131) is a first-in-class synthetic tetrapeptide that selectively targets the mitochondria. It belongs to the Szeto-Schiller (SS) family of peptides, characterized by their ability to cross the blood-brain barrier and penetrate cell membranes without the need for specific transporters.

 

Core Specifications

  • Concentration: 10mg of lyophilized (freeze-dried) powder per vial.

  • Molecular Formula: $C_{32}H_{49}N_{9}O_{5}$

     

  • Molecular Weight: ~$639.8$ g/mol

     

  • Sequence: $D\text{-Arg}-Dmt\text{-Lys-Phe-}NH_2$ (where Dmt is 2,6-dimethyltyrosine).

     

  • Appearance: Fine, white to off-white lyophilized powder.

     

Primary Mechanism of Action

The unique functionality of SS-31 stems from its interaction with Cardiolipin, a phospholipid found exclusively on the inner mitochondrial membrane.

 

  1. Cardiolipin Stabilization: SS-31 binds to cardiolipin, preventing it from undergoing oxidative damage. This stabilizes the mitochondrial cristae structure, which is essential for energy production.

     

  2. ATP Enhancement: By optimizing the electron transport chain (ETC) and improving the organization of mitochondrial "supercomplexes," it facilitates more efficient ATP (cellular energy) synthesis.

     

  3. ROS Scavenging: It significantly reduces the production of Reactive Oxygen Species (ROS), protecting cells from oxidative stress and preventing mitochondrial swelling.

     

  4. Inhibition of mPTP: It helps inhibit the opening of the mitochondrial permeability transition pore (mPTP), a key event that leads to cell death (apoptosis) during times of cellular stress.

     

Research Applications

Area of Study Observed Effects
Neuroprotection Investigated for reversing mitochondrial dysfunction in TBI, Alzheimer’s, and Parkinson’s models.
Cardiovascular Studies focus on its impact on heart failure, ischemia-reperfusion injury, and atherosclerosis.
Metabolic Health Explored for its potential to improve insulin sensitivity and reduce inflammation in Type 2 Diabetes models.
Renal Health Researched for its ability to accelerate ATP recovery and tissue regeneration in acute kidney injuries.

Reconstitution & Storage

  • Diluent: Best reconstituted with bacteriostatic water or sterile 0.9% saline.

  • Mixing: Gentle swirling only. Due to the high concentration of aromatic amino acids, the solution should remain clear and colorless.

  • Storage (Dry): Long-term storage should be at $-20^\circ\text{C}$, protected from light and moisture.

     

  • Storage (Liquid): Once reconstituted, it is recommended to keep the solution refrigerated ($2^\circ\text{C}$ to $8^\circ\text{C}$) and use it within 21 days for optimal research results.

     

Technical Note: SS-31 is particularly favored in research because it does not appear to affect mitochondrial function in healthy cells, only exerting its restorative effects on "stressed" or dysfunctional mitochondria.

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